Neutrophil clearance

Across TCGA pan-cancer cohorts, RNA activity of the Neutrophil clearance pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and LIHC, show the opposite pattern, with lower activity in tumor tissue.

COAD, LIHC, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Female	II,III,IV	−0.072	<.001	9	view →
LIHC	Male	All	−0.063	<.001	9	view →
HNSC	All	All	+0.031	<.001	7	view →
KIRP	Male	III,IV	−0.094	<.001	6	view →
LUSC	All	All	−0.046	<.001	5	view →
CHOL	All	All	−0.082	.005	4	view →
BRCA	All	II,III,IV	−0.024	<.001	4	view →
KICH	All	All	−0.045	.004	3	view →
UCEC	All	All	+0.037	.042	2	view →
KIRC	All	All	+0.022	.002	2	view →
THCA	Male	IV	−0.083	.024	1	view →
BLCA	Female	IV	+0.053	.028	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0097350–COAD

Open the COAD breakdown →