Neutrophil clearance

Across TCGA patient cohorts, RNA activity of the Neutrophil clearance pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPP7, ELAVL4, and FAM163B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil clearance activity versus PLPP7 in GBM (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLPP7 →	-0.648	-0.672	<.001	.001	3	3
GBM	ELAVL4 →	-1.401	-0.811	<.001	.002	3	3
GBM	FAM163B →	-1.565	-0.768	<.001	.001	3	3
PDAC	FREM3 →	-0.116	-0.302	.007	.007	3	3
CCRCC	SYNJ2BP-COX16 →	-0.101	-0.061	.002	.006	2	4
GBM	SEPTIN3 →	-0.761	-0.560	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097350 vs PLPP7 — GBM

Explore this scatter interactively →