Neutrophil clearance

Across TCGA cell cohorts, RNA activity of the Neutrophil clearance pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XKR8, ANXA1, and AXL, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil clearance activity versus XKR8 in OVARY (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	XKR8 →	-1.739	-0.177	<.001	<.001	3	15
LUNG_SCLC	ANXA1 →	+4.762	+0.151	<.001	<.001	1	14
BREAST	AXL →	+3.308	+0.187	<.001	<.001	3	9
BREAST	S100A2 →	+3.738	+0.236	<.001	<.001	3	9
BONE	IL7R →	+2.856	+0.224	<.001	<.001	3	9
BREAST	ARHGAP23 →	+2.198	+0.194	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097350 vs XKR8 — OVARY

Explore this scatter interactively →