Plasma membrane tubulation

Across TCGA patient cohorts, RNA activity of the Plasma membrane tubulation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ILK, MYO1C, and RSU1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane tubulation activity versus ILK in UCEC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ILK →	+0.424	+0.052	.002	<.001	3	9
OV	MYO1C →	+0.446	+0.033	<.001	.002	3	9
COAD	RSU1 →	+0.414	+0.050	<.001	<.001	3	8
UCEC	TNS1 →	+0.596	+0.059	.001	<.001	3	8
OV	TNS2 →	+0.495	+0.057	<.001	<.001	2	9
BRCA	CAVIN2 →	+0.901	+0.037	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097320 vs ILK — UCEC

Explore this scatter interactively →