Plasma membrane tubulation

Across TCGA patient cohorts, RNA activity of the Plasma membrane tubulation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, SELP, and EIF5B_S1168, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane tubulation activity versus RSU1 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RSU1 →	+0.593	+0.362	<.001	<.001	3	6
OV	SELP →	+1.379	+0.666	<.001	.002	3	6
OV	EIF5B_S1168 →	-0.614	-0.749	<.001	<.001	3	6
UCEC	PLAC9 →	+1.090	+0.303	<.001	<.001	3	6
LUAD	VWF →	+0.377	+0.163	<.001	<.001	2	7
OV	CAVIN1_S118 →	+1.478	+1.352	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097320 vs RSU1 — UCEC

Explore this scatter interactively →