Plasma membrane tubulation

Across TCGA cell cohorts, RNA activity of the Plasma membrane tubulation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, USP9Y, and FLYWCH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma membrane tubulation activity versus TSPO in SKIN (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TSPO →	+0.687	+0.821	.001	.003	3	6
BONE	USP9Y →	+2.594	+1.121	.001	.005	3	5
URINARY_TRACT	FLYWCH1 →	+1.115	+1.365	.009	.002	3	5
BLOOD_Lymphoma	RRP7A →	+0.953	+0.920	.001	<.001	3	4
BLOOD_Lymphoma	KANK2 →	+2.150	+1.283	<.001	<.001	3	4
STOMACH	DDX3Y →	+3.700	+1.256	.006	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097320 vs TSPO — SKIN

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