Hepatocyte apoptotic process

Across TCGA cell cohorts, RNA activity of the Hepatocyte apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDST2, ATG4D, and ADCY6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDST2 grouped by Hepatocyte apoptotic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NDST2 →	+1.005	+1.143	.001	.001	3	5
STOMACH	ATG4D →	+0.916	+1.730	.002	<.001	3	4
LUNG_NSCLC_LUSC	ADCY6 →	+1.301	+1.519	.001	.002	3	4
OVARY	UCHL3 →	-0.826	-0.969	<.001	.002	3	4
BREAST	NECAB3 →	+1.008	+0.816	<.001	<.001	3	4
BLOOD_Lymphoma	RAI1 →	+3.313	+1.799	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDST2 by Hepatocyte apoptotic process activity — BREAST

Explore this box plot interactively →