Ammonium homeostasis

Across TCGA patient cohorts, RNA activity of the Ammonium homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLPH3L, MAP3K8, and OGG1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ammonium homeostasis activity versus GOLPH3L in CCRCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GOLPH3L →	-0.266	-0.667	.003	.002	3	3
CCRCC	MAP3K8 →	+0.505	+0.747	.003	.009	3	2
CCRCC	OGG1 →	-0.435	-0.887	.005	.009	3	2
CCRCC	SCAMP3 →	-0.247	-0.774	.004	<.001	3	2
CCRCC	CEP89 →	-0.252	-0.898	.002	.002	3	2
CCRCC	C5AR2 →	+0.631	+0.641	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097272 vs GOLPH3L — CCRCC

Explore this scatter interactively →