Renal tubular secretion

Across TCGA patient cohorts, RNA activity of the Renal tubular secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KNG1, PLVAP, and ASPA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal tubular secretion activity versus KNG1 in BRCA (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KNG1 →	+0.454	+0.050	.007	.001	3	7
CCRCC	PLVAP →	+0.506	+0.109	<.001	<.001	3	7
BRCA	ASPA →	+0.648	+0.050	<.001	.002	3	6
LSCC	SPTBN1_S257 →	+0.580	+0.069	<.001	<.001	3	6
BRCA	TPM1 →	+0.548	+0.058	<.001	<.001	3	6
BRCA	WDR43 →	-0.312	-0.052	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097254 vs KNG1 — BRCA

Explore this scatter interactively →