Mitochondrial respirasome assembly

Across TCGA patient cohorts, RNA activity of the Mitochondrial respirasome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMA4, MAP1A, and LMNB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitochondrial respirasome assembly activity versus LAMA4 in COAD (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LAMA4 →	+0.414	+0.091	<.001	<.001	3	7
CCRCC	MAP1A →	+0.413	+0.048	<.001	.002	3	6
BRCA	LMNB1 →	-0.311	-0.058	<.001	.001	3	6
LSCC	MAP1A_S1311 →	+0.663	+0.050	<.001	.002	3	6
OV	SGCD →	+0.479	+0.045	.009	.002	3	5
OV	SNRPB2 →	-0.190	-0.043	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097250 vs LAMA4 — COAD

Explore this scatter interactively →