Amyloid-beta clearance

Across TCGA patient cohorts, RNA activity of the Amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AQP9, FCGR2A, and CYP1B1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid-beta clearance activity versus AQP9 in COAD (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	AQP9 →	+1.225	+0.180	<.001	<.001	3	7
COAD	FCGR2A →	+0.661	+0.151	<.001	<.001	3	7
COAD	CYP1B1 →	+0.886	+0.158	<.001	<.001	3	6
COAD	LHFPL2 →	+0.523	+0.137	<.001	.007	3	6
LSCC	LILRA5 →	+0.569	+0.157	<.001	<.001	3	6
COAD	EMP3 →	+0.718	+0.201	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097242 vs AQP9 — COAD

Explore this scatter interactively →