Amyloid-beta clearance

Across TCGA cell cohorts, RNA activity of the Amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT9, SLC39A6, and MAPK11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACOT9 grouped by Amyloid-beta clearance-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ACOT9 →	-0.855	-0.185	.001	.004	3	4
OVARY	SLC39A6 →	-0.615	-0.176	.001	.007	2	5
LUNG_NSCLC_LUAD	MAPK11 →	-0.955	-0.291	.001	.008	3	4
LARGE_INTESTINE	ADAT1 →	-0.823	-0.211	.001	.003	3	4
BONE	MED10 →	-0.942	-0.323	.006	.006	2	5
BLOOD_Myeloma	FBXO41 →	+1.216	+0.294	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACOT9 by Amyloid-beta clearance activity — OVARY

Explore this box plot interactively →