Renal filtration

Across TCGA cell cohorts, RNA activity of the Renal filtration pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A33, SLC2A12, and SIN3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A33 grouped by Renal filtration-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLC25A33 →	+1.823	+1.829	<.001	.005	3	5
LUNG_NSCLC_LUAD	SLC2A12 →	+0.756	+0.789	.009	.006	3	4
LUNG_NSCLC_LUAD	SIN3A →	+0.538	+0.887	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	OIP5 →	+1.275	+0.926	.007	.005	3	4
LARGE_INTESTINE	MTR →	+0.882	+1.086	<.001	.001	3	4
LARGE_INTESTINE	CLPX →	+0.746	+1.013	.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A33 by Renal filtration activity — LIVER

Explore this box plot interactively →