Execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Execution phase of apoptosis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUOX2, EDAR, and RNF43, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUOX2 grouped by Execution phase of apoptosis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DUOX2 →	-0.337	-0.307	.003	.001	3	4
LUNG_NSCLC_LUSC	EDAR →	-0.248	-0.455	.005	<.001	3	4
OESOPHAGUS	RNF43 →	-0.152	-0.159	<.001	.001	3	4
LUNG_NSCLC_LUAD	BCL2L1 →	-1.010	-0.277	<.001	<.001	3	4
LUNG_NSCLC_LUAD	KLHL9 →	+0.104	+0.165	.001	.002	3	4
BLOOD_Myeloma	CHD1 →	+0.258	+0.312	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUOX2 by Execution phase of apoptosis activity — BLOOD_Lymphoma

Explore this box plot interactively →