Dentinogenesis

Across TCGA patient cohorts, RNA activity of the Dentinogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINE1, CRELD2_S70, and LRPAP1_S50, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dentinogenesis activity versus SERPINE1 in GBM (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINE1 →	+1.078	+0.133	<.001	<.001	3	7
LUAD	CRELD2_S70 →	+0.722	+0.107	.001	.001	3	7
LSCC	LRPAP1_S50 →	+0.885	+0.122	<.001	<.001	3	7
OV	C1QA →	+0.727	+0.158	<.001	<.001	3	6
OV	C1QB →	+0.627	+0.118	<.001	<.001	3	6
GBM	ITGAM →	+0.833	+0.148	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097187 vs SERPINE1 — GBM

Explore this scatter interactively →