Epoxide metabolic process

Across TCGA patient cohorts, RNA activity of the Epoxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C16orf54, DCN, and ALOX5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epoxide metabolic process activity versus C16orf54 in OV (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C16orf54 →	+1.138	+0.153	<.001	.005	3	8
BRCA	DCN →	+1.213	+0.085	<.001	<.001	3	7
OV	ALOX5 →	+1.995	+0.199	<.001	.001	3	7
COAD	C1orf162 →	+0.726	+0.069	<.001	<.001	3	7
OV	CD6 →	+1.119	+0.175	<.001	.002	3	7
OV	JAML →	+1.728	+0.188	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097176 vs C16orf54 — OV

Explore this scatter interactively →