Epoxide metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Epoxide metabolic process pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Epoxide metabolic process pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and MESO, show the opposite pattern, with higher activity associated with better survival.

HNSC, MESO, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.394	0.201	<.001	100	view →
MESO	DFS	Median	II,III,IV	0.468	0.287	.003	92	view →
ACC	OS	Tertile	All	0.853	0.284	<.001	78	view →
CESC	OS	Quartile	II,III,IV	0.911	0.625	.001	74	view →
OV	DFS	Quartile	II,III,IV	0.313	0.452	<.001	54	view →
LUSC	DFS	Tertile	III,IV	0.583	0.183	.001	51	view →
KIRP	OS	Quartile	II,III,IV	0.831	0.174	<.001	46	view →
UCS	DFS	Median	IV	0.394	0.841	.019	30	view →
GBM	OS	Median	All	0.284	0.525	.002	28	view →
PAAD	OS	Median	All	0.299	0.588	.001	18	view →
LIHC	OS	Median	All	0.745	0.624	.003	17	view →
SARC	OS	Quartile	All	0.906	0.759	.002	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0097176–HNSC (DFS)

Open the HNSC breakdown →