Epoxide metabolic process

Across TCGA cell cohorts, RNA activity of the Epoxide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRIN1, ZNF124, and TMBIM6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPRIN1 grouped by Epoxide metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPRIN1 →	-1.132	-1.017	.002	.006	2	5
OESOPHAGUS	ZNF124 →	-0.974	-1.347	.003	.002	3	4
OVARY	TMBIM6 →	+0.856	+1.453	<.001	<.001	3	4
LUNG_NSCLC_LUAD	RPL11 →	-0.760	-0.923	.002	.008	3	4
OVARY	ZNF644 →	-1.033	-1.358	<.001	.001	3	3
LUNG_NSCLC_LUAD	ZBTB24 →	-0.540	-1.280	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPRIN1 by Epoxide metabolic process activity — OESOPHAGUS

Explore this box plot interactively →