Receptor localization to synapse

Across TCGA cell cohorts, RNA activity of the Receptor localization to synapse pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL3, TDG, and TSNARE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor localization to synapse activity versus RPL3 in BLOOD_Myeloma (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	RPL3 →	+0.840	+0.401	.002	<.001	3	5
SKIN	TDG →	-0.650	-0.247	.003	.003	3	5
OESOPHAGUS	TSNARE1 →	+1.305	+0.223	<.001	.003	3	4
OESOPHAGUS	SHARPIN →	+0.776	+0.287	.001	<.001	3	4
SKIN	EFNA5 →	-1.397	-0.326	.002	.004	3	4
CNS	LIMD1 →	+0.602	+0.280	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097120 vs RPL3 — BLOOD_Myeloma

Explore this scatter interactively →