Postsynaptic density protein 95 clustering

Across TCGA patient cohorts, RNA activity of the Postsynaptic density protein 95 clustering pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLASP1, RNASEL, and CDH2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic density protein 95 clustering activity versus CLASP1 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLASP1 →	+0.302	+0.063	<.001	<.001	3	6
BRCA	RNASEL →	-0.427	-0.054	<.001	.002	3	5
LUAD	CDH2 →	+1.175	+0.103	<.001	<.001	3	5
OV	EPB41L2_S614 →	-0.723	-0.104	.008	.005	3	5
LSCC	SNRPD3 →	+0.212	+0.074	<.001	.003	3	5
COAD	SNX18 →	-0.349	-0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097119 vs CLASP1 — BRCA

Explore this scatter interactively →