Postsynaptic density protein 95 clustering

Across TCGA pan-cancer cohorts, RNA activity of the Postsynaptic density protein 95 clustering pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as READ, show the opposite pattern, with lower activity in tumor tissue.

KIRC, KIRP, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRC	Female	All	+0.069	<.001	11	view →
KIRP	Male	III,IV	+0.117	<.001	8	view →
HNSC	Male	IV	+0.104	<.001	8	view →
BLCA	All	All	+0.095	<.001	8	view →
THCA	Female	II,III,IV	+0.090	<.001	8	view →
BRCA	Female	II,III,IV	+0.042	<.001	6	view →
LUSC	Female	II,III,IV	+0.157	<.001	5	view →
LUAD	All	All	+0.045	<.001	5	view →
LIHC	All	All	+0.028	.001	5	view →
UCEC	All	All	+0.064	.004	2	view →
READ	Female	All	−0.103	.035	1	view →
COAD	All	All	+0.032	.022	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:0097119–KIRC

Open the KIRC breakdown →