Postsynaptic density protein 95 clustering

Across TCGA cell cohorts, RNA activity of the Postsynaptic density protein 95 clustering pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMD, TBC1D32, and SUGT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DMD grouped by Postsynaptic density protein 95 clustering-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DMD →	+3.041	+1.254	.002	.007	3	4
BLOOD_Myeloma	TBC1D32 →	+1.109	+1.761	<.001	<.001	3	4
URINARY_TRACT	SUGT1 →	-1.032	-1.670	<.001	<.001	3	4
SOFT_TISSUE	CNDP2 →	-0.867	-1.396	.009	.003	3	4
SOFT_TISSUE	NEK3 →	-1.524	-1.559	.001	<.001	3	4
PANCREAS	ZNF354C →	+1.452	+1.240	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DMD by Postsynaptic density protein 95 clustering activity — SOFT_TISSUE

Explore this box plot interactively →