AMPA glutamate receptor clustering

Across TCGA patient cohorts, RNA activity of the AMPA glutamate receptor clustering pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAB1, CAMSAP3, and FHL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, AMPA glutamate receptor clustering activity versus STAB1 in LSCC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STAB1 →	+0.284	+0.068	.001	<.001	3	6
LSCC	CAMSAP3 →	-0.268	-0.037	.006	.006	3	5
UCEC	FHL1 →	+0.831	+0.079	.001	<.001	3	5
BRCA	PPP3CB →	+0.288	+0.044	<.001	<.001	3	5
HNSC	SYNPO2_S675 →	+0.676	+0.050	.001	.008	3	4
HNSC	SYNPO2_T755 →	+0.586	+0.057	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097113 vs STAB1 — LSCC

Explore this scatter interactively →