Postsynaptic membrane assembly

Across TCGA patient cohorts, RNA activity of the Postsynaptic membrane assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMC1, ZDHHC5_T348, and CHPF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic membrane assembly activity versus LAMC1 in UCEC (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAMC1 →	+0.421	+0.077	.004	.003	3	6
OV	ZDHHC5_T348 →	-0.575	-0.060	.007	.008	3	6
OV	CHPF →	+0.384	+0.084	.006	<.001	3	6
UCEC	SEPTIN11 →	+0.294	+0.057	<.001	.005	3	6
UCEC	PCOLCE →	+0.663	+0.102	<.001	.001	3	6
GBM	VAMP8 →	-0.590	-0.089	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097104 vs LAMC1 — UCEC

Explore this scatter interactively →