Postsynaptic membrane assembly

Across TCGA cell cohorts, RNA activity of the Postsynaptic membrane assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALR, GDI1, and PRKD2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALR grouped by Postsynaptic membrane assembly-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CALR →	-0.926	-1.106	<.001	.001	3	3
BLOOD_Myeloma	GDI1 →	+1.148	+1.397	.003	.002	3	3
URINARY_TRACT	PRKD2 →	+0.877	+1.354	.004	.005	3	3
SKIN	OSGIN2 →	-0.499	-0.673	.002	.007	3	3
BLOOD_Lymphoma	ZBTB39 →	-0.796	-1.764	<.001	<.001	3	3
LUNG_SCLC	SUOX →	+0.848	+0.951	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALR by Postsynaptic membrane assembly activity — BLOOD_Myeloma

Explore this box plot interactively →