Postsynaptic membrane assembly

Across TCGA cell cohorts, RNA activity of the Postsynaptic membrane assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFX1, FAM162A, and HTD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NFX1 grouped by Postsynaptic membrane assembly-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NFX1 →	-0.184	-0.143	.006	.002	3	4
BONE	FAM162A →	+0.260	+0.354	.009	.004	3	4
BONE	HTD2 →	-0.160	-0.232	.009	.006	2	5
BLOOD_Lymphoma	TPI1 →	-0.387	-1.877	.004	<.001	3	4
KIDNEY	SMARCD2 →	-0.198	-0.124	.002	.007	3	3
KIDNEY	TNNI2 →	-0.219	-0.163	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NFX1 by Postsynaptic membrane assembly activity — SOFT_TISSUE

Explore this box plot interactively →