Synaptic vesicle clustering

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle clustering pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H10, SYT7, and MIR502, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle clustering activity versus ZC3H10 in HNSC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZC3H10 →	-0.340	-0.829	.002	.002	3	4
GBM	SYT7 →	+1.762	+2.402	<.001	<.001	3	4
GBM	MIR502 →	+0.535	+1.284	.009	.002	3	4
PDAC	MLXIPL →	+0.884	+0.757	<.001	<.001	3	3
GBM	IL2RA →	-1.082	-1.576	<.001	<.001	3	3
HNSC	SNX22 →	-0.492	-1.008	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097091 vs ZC3H10 — HNSC

Explore this scatter interactively →