Synaptic vesicle clustering

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle clustering pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRYD4, DNLZ, and CACTIN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPRYD4 grouped by Synaptic vesicle clustering-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SPRYD4 →	-1.523	-2.254	.009	<.001	3	4
BREAST	DNLZ →	-0.912	-1.339	<.001	<.001	3	4
BREAST	CACTIN →	-0.486	-0.926	.007	.008	3	4
LUNG_SCLC	UBE2S →	-1.342	-0.885	<.001	.002	3	4
BLOOD_Leukemia	OCIAD2 →	-3.384	-1.144	<.001	.001	3	4
CNS	SPG11 →	+0.704	+1.314	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPRYD4 by Synaptic vesicle clustering activity — BLOOD_Lymphoma

Explore this box plot interactively →