Synaptic vesicle clustering

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle clustering pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLCO3A1, CDH2, and COL18A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle clustering activity versus SLCO3A1 in CNS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLCO3A1 →	+1.202	+0.263	.006	.002	3	5
OESOPHAGUS	CDH2 →	+2.925	+0.428	.009	<.001	2	6
KIDNEY	COL18A1 →	+1.561	+0.220	.003	.008	3	5
STOMACH	ABHD5 →	+1.247	+0.320	.004	<.001	3	4
PANCREAS	PAM16 →	-1.003	-0.370	<.001	<.001	3	4
PANCREAS	ARAP2 →	+1.163	+0.271	.006	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097091 vs SLCO3A1 — CNS

Explore this scatter interactively →