Presynaptic membrane organization

Across TCGA patient cohorts, RNA activity of the Presynaptic membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VSNL1, NADK, and PRNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic membrane organization activity versus VSNL1 in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VSNL1 →	+1.063	+0.149	<.001	<.001	3	6
LSCC	NADK →	-0.372	-0.090	<.001	<.001	3	6
GBM	PRNP →	+0.569	+0.156	<.001	<.001	3	6
OV	DKK3 →	+0.766	+0.089	.003	<.001	2	6
OV	GCC1 →	-0.202	-0.074	.002	<.001	3	5
OV	GPRIN3_S32 →	-0.983	-0.077	.003	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097090 vs VSNL1 — GBM

Explore this scatter interactively →