Presynaptic membrane organization

Across TCGA patient cohorts, RNA activity of the Presynaptic membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR6746, ARSA, and MGAT3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic membrane organization activity versus MIR6746 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR6746 →	+0.810	+0.226	<.001	<.001	3	3
BRCA	ARSA →	+0.570	+0.566	.005	.002	3	3
UCEC	MGAT3 →	-0.811	-0.602	.001	.001	3	3
BRCA	TARBP2 →	+0.477	+0.574	.002	.003	3	3
BRCA	CERS5 →	+0.369	+0.713	.001	<.001	3	3
HNSC	FOXN2 →	-0.577	-0.808	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097090 vs MIR6746 — GBM

Explore this scatter interactively →