Presynaptic membrane organization

Across TCGA cell cohorts, RNA activity of the Presynaptic membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD8, CHSY1, and ANKRD50, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABHD8 grouped by Presynaptic membrane organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ABHD8 →	+1.377	+1.209	<.001	.002	3	4
OVARY	CHSY1 →	+0.859	+0.747	<.001	.006	3	4
LUNG_SCLC	ANKRD50 →	+1.126	+0.917	<.001	.008	3	3
LUNG_SCLC	PEX2 →	+0.961	+1.017	.002	.006	3	3
KIDNEY	NR1D1 →	+0.902	+1.237	.003	.009	3	3
KIDNEY	SYNM →	+1.331	+1.166	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABHD8 by Presynaptic membrane organization activity — BLOOD_Leukemia

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