Vascular associated smooth muscle cell development

Across TCGA cell cohorts, RNA activity of the Vascular associated smooth muscle cell development pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALG1L, ADGRF1, and ESD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALG1L grouped by Vascular associated smooth muscle cell development-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ALG1L →	+1.488	+0.418	.008	.007	2	4
LARGE_INTESTINE	ADGRF1 →	+2.300	+0.573	.006	.007	2	4
CNS	ESD →	-0.560	-0.884	.002	.004	3	3
CNS	LRRC8D →	+0.760	+0.655	.005	.009	3	3
KIDNEY	PCDH1 →	+1.995	+1.337	.001	.001	3	3
KIDNEY	TAPT1 →	+1.361	+1.342	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALG1L by Vascular associated smooth muscle cell development activity — OESOPHAGUS

Explore this box plot interactively →