Response to thyroxine

Across TCGA patient cohorts, RNA activity of the Response to thyroxine pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GCLM, GCLC, and GCLC_S8, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to thyroxine activity versus GCLM in LSCC (Pearson r = 0.80).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GCLM →	+1.282	+0.240	<.001	<.001	3	10
LSCC	GCLC →	+1.219	+0.213	<.001	<.001	3	8
LSCC	GCLC_S8 →	+1.407	+0.215	<.001	<.001	3	6
UCEC	GATD1 →	-0.182	-0.127	.001	<.001	3	6
LSCC	PGD →	+0.788	+0.204	<.001	<.001	3	6
OV	RHBDF2 →	+0.363	+0.059	.008	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097068 vs GCLM — LSCC

Explore this scatter interactively →