Response to thyroxine

Across TCGA cell cohorts, RNA activity of the Response to thyroxine pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf88, C17orf80, and POLR2K, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C10orf88 grouped by Response to thyroxine-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C10orf88 →	+0.498	+0.235	<.001	<.001	3	5
OESOPHAGUS	C17orf80 →	+0.562	+0.186	.002	.005	3	4
OESOPHAGUS	POLR2K →	+0.534	+0.204	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	UHRF2 →	+1.772	+0.239	.007	.007	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF440 →	+1.534	+0.291	<.001	.004	3	4
BLOOD_Leukemia	SGCA →	-0.173	-0.204	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C10orf88 by Response to thyroxine activity — OESOPHAGUS

Explore this box plot interactively →