Response to thyroxine

Across TCGA cell cohorts, RNA activity of the Response to thyroxine pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLIP4, SLC12A9, and USP7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to thyroxine activity versus CLIP4 in LIVER (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CLIP4 →	+2.598	+0.256	.003	.007	3	6
SKIN	SLC12A9 →	-0.822	-0.157	.002	.002	3	5
OVARY	USP7 →	-0.742	-0.183	.001	.004	3	5
OVARY	TCF19 →	-0.979	-0.169	.005	.002	2	5
SKIN	TM4SF19 →	+1.710	+0.142	.009	.006	3	4
SKIN	SSBP2 →	-1.234	-0.152	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097068 vs CLIP4 — LIVER

Explore this scatter interactively →