Cellular response to thyroid hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to thyroid hormone stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCERG1, TOP1, and IK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to thyroid hormone stimulus activity versus TCERG1 in GBM (Pearson r = -0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TCERG1 →	-0.201	-0.076	<.001	<.001	3	7
BRCA	TOP1 →	-0.351	-0.060	<.001	<.001	3	7
GBM	IK →	-0.205	-0.075	<.001	<.001	3	7
BRCA	SYNPO2 →	+0.516	+0.049	<.001	<.001	3	7
BRCA	PALMD →	+0.698	+0.085	<.001	<.001	3	7
LSCC	AHNAK_S5448 →	+0.692	+0.071	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097067 vs TCERG1 — GBM

Explore this scatter interactively →