Anterior head development

pathway activity — cross-omics
GO:0097065Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Anterior head development pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SOX9, SETDB1, and NUP93_S52, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCSOX9 →+1.122+0.127<.001<.00135
HNSCSETDB1 →+0.141+0.069.001.00134
PDACNUP93_S52 →+0.341+0.041<.001.00534
BRCABUD13 →+0.239+0.055<.001.00134
LSCCRNF220 →+0.244+0.113.001<.00134
HNSCSRRM2_S1436 →+0.215+0.069<.001<.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration