Motor neuron apoptotic process

Across TCGA patient cohorts, RNA activity of the Motor neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAGH, MESD, and HIP1R, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motor neuron apoptotic process activity versus HAGH in GBM (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HAGH →	+0.223	+0.624	<.001	<.001	3	5
LUAD	MESD →	-0.244	-0.255	.009	.007	3	4
GBM	HIP1R →	+0.568	+0.552	<.001	.001	3	4
GBM	ARRB1 →	+0.712	+0.804	<.001	<.001	3	4
GBM	CENPE →	-0.873	-0.746	<.001	<.001	3	4
GBM	CBX7 →	+0.632	+1.035	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097049 vs HAGH — GBM

Explore this scatter interactively →