Motor neuron apoptotic process

Across TCGA cell cohorts, RNA activity of the Motor neuron apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRADC1, TMEM150B, and WDR36, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRADC1 grouped by Motor neuron apoptotic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRADC1 →	+1.505	+2.120	.002	<.001	3	4
STOMACH	TMEM150B →	+1.955	+1.651	.005	<.001	3	4
CNS	WDR36 →	+1.145	+2.120	.006	<.001	3	4
CNS	MALSU1 →	+1.994	+2.120	.002	<.001	3	4
CNS	PLEKHA2 →	+3.467	+2.120	<.001	<.001	3	4
STOMACH	SUCLG1 →	+0.859	+1.415	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRADC1 by Motor neuron apoptotic process activity — CNS

Explore this box plot interactively →