Protein linear polyubiquitination

Across TCGA patient cohorts, RNA activity of the Protein linear polyubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OAS3, STAT1, and IFIH1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein linear polyubiquitination activity versus OAS3 in PDAC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	OAS3 →	+0.615	+0.054	<.001	<.001	3	7
LSCC	STAT1 →	+0.534	+0.052	<.001	.001	3	6
LSCC	IFIH1 →	+0.608	+0.074	<.001	<.001	3	6
OV	IFIH1_S301 →	+0.805	+0.069	<.001	<.001	3	6
GBM	PARP14 →	+0.314	+0.063	<.001	<.001	3	6
LSCC	PARP9 →	+0.486	+0.080	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097039 vs OAS3 — PDAC

Explore this scatter interactively →