Lymphocyte migration into lymphoid organs

Across TCGA patient cohorts, RNA activity of the Lymphocyte migration into lymphoid organs pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCOR1_S224, BCL11B_T260, and PTPRE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte migration into lymphoid organs activity versus NCOR1_S224 in GBM (Pearson r = 0.04).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCOR1_S224 →	+0.316	+0.069	.001	<.001	3	5
LSCC	BCL11B_T260 →	+0.679	+0.082	.001	.001	3	4
BRCA	PTPRE →	+0.305	+0.036	<.001	.002	3	4
CCRCC	SEPTIN1 →	+0.591	+0.089	<.001	<.001	3	4
OV	SLC9A9 →	+0.599	+0.066	<.001	<.001	3	4
BRCA	STAT5A →	+0.363	+0.034	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097021 vs NCOR1_S224 — GBM

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