Renal albumin absorption

pathway activity — cross-omics
GO:0097018Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Renal albumin absorption pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL18A1, RECK, and RRP1B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCACOL18A1 →+0.370+0.069<.001<.00138
BRCARECK →+0.313+0.037.004.00937
BRCARRP1B →-0.426-0.078<.001<.00137
BRCARSL1D1 →-0.584-0.087<.001<.00137
GBMRSU1 →+0.278+0.077.004.00137
BRCASERPINA5 →+0.495+0.059<.001<.00137
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration