Regulation of plasma lipoprotein particle levels

Across TCGA cell cohorts, RNA activity of the Regulation of plasma lipoprotein particle levels pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLG3, HMOX1, and PLOD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma lipoprotein particle levels activity versus DLG3 in LUNG_SCLC (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DLG3 →	-1.914	-0.071	<.001	.001	3	10
OVARY	HMOX1 →	+2.158	+0.102	.001	.001	3	10
BREAST	PLOD1 →	+1.845	+0.106	<.001	<.001	3	9
BREAST	P3H1 →	+1.326	+0.071	<.001	<.001	3	9
LUNG_SCLC	SECISBP2 →	-0.772	-0.090	<.001	<.001	2	10
BREAST	MAP3K6 →	+0.929	+0.077	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097006 vs DLG3 — LUNG_SCLC

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