Regulation of plasma lipoprotein particle levels

Across TCGA cell cohorts, RNA activity of the Regulation of plasma lipoprotein particle levels pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCOA2, C19orf54, and CCDC167, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma lipoprotein particle levels activity versus NCOA2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NCOA2 →	-1.191	-0.241	.004	.002	3	5
STOMACH	C19orf54 →	-1.448	-0.354	.002	.007	2	5
BLOOD_Leukemia	CCDC167 →	-0.979	-1.030	.002	.002	2	5
LUNG_NSCLC_LUAD	LAMC1 →	+0.774	+0.506	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	STC2 →	+1.469	+0.283	<.001	<.001	3	4
SOFT_TISSUE	ZNF687 →	-0.860	-1.536	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097006 vs NCOA2 — UPPER_AERODIGESTIVE_TRACT

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