Immunological memory formation process

pathway activity — cross-omics
GO:0090715Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Immunological memory formation process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LENG1, BCL6, and EXTL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMLENG1 →-0.266-0.594.003.00133
UCECBCL6 →+0.770+0.642<.001<.00133
GBMEXTL3 →-0.625-0.544<.001<.00133
GBMDRC7 →+0.571+0.572.002<.00133
CCRCCRN7SKP137 →+0.866+0.772.001<.00133
COADECHDC3 →+0.799+0.401<.001.00224
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration