scaRNA localization to Cajal body

Across TCGA patient cohorts, RNA activity of the scaRNA localization to Cajal body pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NKRF, TFB2M, and WDR12, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, scaRNA localization to Cajal body activity versus NKRF in UCEC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NKRF →	+0.367	+0.110	<.001	<.001	3	9
LUAD	TFB2M →	+0.546	+0.041	<.001	.001	3	8
LSCC	WDR12 →	+0.394	+0.051	.002	<.001	3	8
BRCA	DDX10 →	+0.365	+0.033	<.001	<.001	3	8
BRCA	DNAJC2 →	+0.401	+0.041	<.001	<.001	3	8
LSCC	HEATR1 →	+0.387	+0.053	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090666 vs NKRF — UCEC

Explore this scatter interactively →