Walking behavior

Across TCGA cell cohorts, RNA activity of the Walking behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLRB, HDAC5, and PIP5K1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GLRB grouped by Walking behavior-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GLRB →	-0.371	-1.284	<.001	.007	3	5
SKIN	HDAC5 →	+0.144	+0.899	.006	<.001	3	5
CNS	PIP5K1B →	-0.144	-0.983	.004	.001	3	4
LARGE_INTESTINE	POLR2J2 →	-0.237	-0.961	<.001	.001	3	4
PANCREAS	CHRM3 →	-0.164	-1.258	.001	.004	3	4
SKIN	WDR3 →	+0.285	+1.040	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GLRB by Walking behavior activity — SOFT_TISSUE

Explore this box plot interactively →