Telomeric loop disassembly

Across TCGA patient cohorts, RNA activity of the Telomeric loop disassembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, RPL12_S38, and SMC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Telomeric loop disassembly activity versus RFC1_T506 in LSCC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC1_T506 →	+1.314	+0.089	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.270	+0.083	<.001	<.001	3	10
LUAD	SMC4 →	+0.660	+0.087	<.001	<.001	3	10
LUAD	TK1 →	+0.729	+0.079	<.001	<.001	3	10
LUAD	FEN1 →	+0.495	+0.086	<.001	<.001	3	10
LUAD	MCM2 →	+0.875	+0.090	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0090657 vs RFC1_T506 — LSCC

Explore this scatter interactively →