Telomeric loop disassembly

Across TCGA cell cohorts, RNA activity of the Telomeric loop disassembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNG1, PDZRN4, and SESN1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CACNG1 grouped by Telomeric loop disassembly-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CACNG1 →	-0.410	-1.773	.002	<.001	3	3
BLOOD_Leukemia	PDZRN4 →	+0.106	+1.980	.005	<.001	3	3
BLOOD_Leukemia	SESN1 →	+0.230	+2.005	.009	.001	3	2
BLOOD_Lymphoma	ZBTB17 →	-0.350	-1.773	.004	<.001	3	2
BLOOD_Lymphoma	MEN1 →	+0.259	+1.773	.003	<.001	3	2
BLOOD_Lymphoma	CHST4 →	+0.136	+1.773	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CACNG1 by Telomeric loop disassembly activity — BLOOD_Lymphoma

Explore this box plot interactively →